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An intense precipitation event causes a temperate forested drainage network to shift from N₂O source to sink

https://doi.org/10.1002/lno.12006

Aho, Kelly S.; Fair, Jennifer H.; Hosen, Jake D.; Kyzivat, Ethan D.; Logozzo, Laura A.; Weber, Lisa C.; Yoon, Byungman; Zarnetske, Jay P.; Raymond, Peter A. (February 2022, Limnology and Oceanography)

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Export of photolabile and photoprimable dissolved organic carbon from the Connecticut River

https://doi.org/10.1007/s00027-021-00778-8

Yoon, Byungman; Hosen, Jacob D.; Kyzivat, Ethan D.; Fair, Jennifer H.; Weber, Lisa C.; Aho, Kelly S.; Lowenthal, Rachel; Matt, Serena; Sobczak, William V.; Shanley, Jamie B.; et al (April 2021, Aquatic Sciences)
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Non-equilibrium structural dynamics of supercoiled DNA plasmids exhibits asymmetrical relaxation

https://doi.org/10.1093/nar/gkac101

Shaheen, Cynthia; Hastie, Cameron; Metera, Kimberly; Scott, Shane; Zhang, Zhi; Chen, Sitong; Gu, Gracia; Weber, Lisa; Munsky, Brian; Kouzine, Fedor; et al (February 2022, Nucleic Acids Research)

Abstract Many cellular processes occur out of equilibrium. This includes site-specific unwinding in supercoiled DNA, which may play an important role in gene regulation. Here, we use the Convex Lens-induced Confinement (CLiC) single-molecule microscopy platform to study these processes with high-throughput and without artificial constraints on molecular structures or interactions. We use two model DNA plasmid systems, pFLIP-FUSE and pUC19, to study the dynamics of supercoiling-induced secondary structural transitions after perturbations away from equilibrium. We find that structural transitions can be slow, leading to long-lived structural states whose kinetics depend on the duration and direction of perturbation. Our findings highlight the importance of out-of-equilibrium studies when characterizing the complex structural dynamics of DNA and understanding the mechanisms of gene regulation.
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